Effect of Methyl-?-Cyclodextrin on the Interaction of Fluoroquinolones with Human Serum Albumin

Abstract— The influence of the structure fluoroquinolones (on example ciprofloxacin and levofloxacin) their complexation with methyl-?-cyclodextrin on interaction drug human serum albumin was studied. It found that binding molecule is significantly affected by fluoroquinolone, as well presence methyl-?-cyclodextrin. discovered two fluoroquinolones, more hydrophobic interacts strongly protein, using circular dichroism fluorescence spectroscopy methods. has also been shown to causes quenching protein fluorescence, this effect pronounced for ciprofloxacin. leads a change in protein: case complexes, interactions are observed levofloxacin. results obtained will help bring use new level clinical practice, creating highly effective drugs improved properties.